Researchers on the Division of Microbiology of The College of Hong Kong (HKU) have discovered that the COVID19 virus could cause acute testicular injury, continual uneven testicular atrophy, and hormonal modifications in hamsters regardless of a light-weight pneumonia.
“In managing convalescent COVID-19 males, it is very important concentrate on doable hypogonadism (low intercourse drive) and subfertility,” mentioned Chair of Infectious Ailments Professor Kwok-yung Yuen, who led the analysis effort. “ COVID-19 vaccination can stop this complication.”
The HKU examine of testicular injury of the virus, SARS-CoV-2, has been accepted for publication within the main journal Medical Infectious Ailments.
Earlier research have reported testicular ache in COVID-19 sufferers. One post-mortem examine of males who died from COVID-19 confirmed orchitis with numerous testicular cell injury, however SARS -CoV-2 was not constantly present in semen specimens.
The HKU staff investigated the testicular and hormonal modifications of hamsters contaminated by virus given via the intranasal or direct testicular route utilizing the influenza virus within the management group. The analysis finds that virus-infected hamsters developed self-limiting pneumonia. However even intranasal SARS-CoV-2 problem prompted acute lower in sperm depend, and serum testosterone ranging from the 4 to 7 days. The SARS-CoV-2 contaminated hamsters developed testicular atrophy with decreased testicular dimension and weight. The serum intercourse hormone stage was markedly decreased at 42 to 120 days after an infection (dpi). Acute testicular irritation, haemorrhage, and necrosis of seminiferous tubules, and disruption of spermatogenesis have been seen.
From 7 to 120 dpi, the irritation, degeneration, and necrosis of testicular tissue endured. Intranasal problem with Omicron and Delta variants have been discovered to induce related testicular modifications. These testicular damages could be prevented by vaccination.
The management group of hamsters challenged by influenza A virus given intranasally or intra-testicularly confirmed no testicular an infection or injury.
Reference: “Extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by intranasal or testicular inoculation induces testicular injury preventable by vaccination in golden Syrian hamsters” by Can Li, Zhanhong Ye, Anna Jin-Xia Zhang, Jasper Fuk-Woo Chan, Wenchen Track, Feifei Liu, Yanxia Chen, Mike Yat-Wah Kwan, Andrew Chak-Yiu Lee, Yan Zhao, Bosco Ho-Yin Wong, Cyril Chik-Yan Yip, Jian-Piao Cai, David Christopher Lung, Siddharth Sridhar, Dongyan Jin, Hin Chu, Kelvin Kai-Wang To and Kwok-Yung Yuen, Accepted, Medical Infectious Ailments.
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